The rising incidence of type 2 diabetes among children and adults is connected to the epidemic of obesity. Both diabetes and obesity are related to insulin resistance. Most obese individuals, in spite of being insulin resistant, do not develop hyperglycemia. Pancreatic ?-cells of the islet of Langerhans release adequate amounts of insulin that are enough to overcome insulin level reductions under normal circumstances, thus maintaining normal glucose tolerance. Throughout the natural history of type 2 diabetes, endothelial dysfunction is gone together with obesity/insulin resistance in diabetes and pre-diabetes conditions. In order to increase insulin resistance and obesity, thereby causing diabetes. Recent advances and the current trend in the pharmacotherapy and etiology, pathophysiology, medical complications of obesity can be discussed in this session.
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